- To Change Your Mind - Details Matter
Undermethylation and Depression – Walsh Biotypes
ADHD Medication 5 Videos – Stimulants Explained – AMP vs MPH
August 31, 2014TotallyADD, Rick Green, Parker & Galileo
September 21, 2014Undermethylation & Depression Biotypes: – 1 of 5 Subsets
The challenge is to carefully identify the specific nutrient overloads and deficiencies possessed by an individual, and to provide treatments that normalize blood and brain levels of these chemicals with rifle shot precision. This is the essence of biochemical therapy.
~ William Walsh
Introduction – Undermethylation – WD1
Undermethylation is associated with perfectionism, strong will, high accomplishment, OCD tendencies, and seasonal allergies… more than two-thirds of persons diagnosed with a behavior or mental disorder exhibit a methylation imbalance.
~ William Walsh
Marker: Depression Biotypes – Walsh
Bill Walsh is a mind pioneer. This brief video describes WD1 – Walsh Depression biotype 1 [1 of 5], and will likely whet your appetite for investigating the fact that depression is more than just an appearance of sadness. Undermethylated depression will prove untreatable if not measured and addressed. I'll report for you here at CorePsych the other four as time permits.
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Important Note
A significant number of undermethylated depression patients exhibit some degree of pyrrole disorder. Many persons with this combination of imbalances exhibit high accomplishment throughout life, but report extreme internal anxiety and poor stress control along with depression . Since both undermethylation and pyrrole disorder are associated with low serotonin activity, depression is usually more severe in these cases. Our database studies indicate persons with this hybrid condition are more likely to report suicidal thoughts compared to persons with any other form of depression.1
From appearances to measurable science – biotype laboratory neurophysiological assessments will change treatment outcomes for depression and a variety of other mind-presentations. Markers matter. Laboratory assessments do improve predictability for challenging clinical outcomes – read: treatment failure.
Dr William Walsh: CorePsych Critical Thinker
Dr Walsh has presented his research at the American Psychiatric Association, the U.S. Senate, the National Institute of Mental Health, the Society for Neuroscience, and has been a speaker at more than 30 international conferences. He has authored more than 200 scientific articles and reports, and has five patents.
Dr Walsh has researched biomedical details for individuals previously considered as untreatable: from personality disorders to others insufficiently treatable with modern psychopharmacology. He's published research and biomedical evaluations on lost souls from murderers to those more commonplace presentations of untreatable depression and ADHD. Think: new options for treatment failure at any level of mind alteration.
If you're interested in learning more about his groundbreaking work consider attending his Walsh Research Institute meeting in Chicago Oct. 18-22, next month.
Back to refractory depression: First the video and then a brief discussion of undermethylation: 4, 5
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Undermethylation and Depression – 1:32 Min
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Symptoms and Traits of Undermethylation
These replicable medical findings clearly encourage more complete assessments – Summarized from Nutrient Power1 Walsh's most recent book, with all the details of how to specifically both measure and treat this specific, easily identified form of depression. *Don't let the nutritional title trivialize your response. Read this book. Measure for methylation imbalances via whole blood histamine.
Important indicators of this syndrome include a whole blood histamine level above 70 ng/ml and a depressed SAMe/SAH ratio 7 in combination with key symptoms and traits including OCD tendencies, seasonal allergies and a history of perfectionism.1
Treat the underlying undermethylation problem as it looks in your life, your offices. We now measure for these methylation issues at CorePsych.
Clinical Characteristics
Characteristics of Undermethylation – 38% of clinical depression [n – 2800]:
- good response to SSRIs – reduced serotonin and dopamine
- self-motivated – [read: loner]
- low tolerance for pain
- very strong-willed
- high suicidal tendency
- sparse chest leg and arm hair
- denial of depression
- addictiveness
- noncompliance with therapies [read: do it yourself – DIY]
- oppositional defiant as a child6
Do you see anything familiar in treatment refractory individuals you know or treat? Did the words addiction and suicide catch your attention? Do you think that non-compliance, denial, and oppositional behaviors are clinically significant?
Undermethylation Treatment Response Time3
Expect little/no improvement during the first three to four weeks, followed by steady improvement during months two to six.
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Dr Walsh Introduces The Five Types Of Depression – 1:08 min
Four More Depression Biotypes: On CorePsych
See: CorePsych Posts on the additional four Walsh depression biotypes,2
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Download Overview Of Walsh Testing at CorePsych :
- Four pages on Specific Reasons and Outcome Details For Assessment:
- Walsh on The CorePsych Critical Thinking page:
http://corepsych.com/critical - Epigenetics: Two excellent video explanations:
http://www.corepsych.com/2013/08/epigenetics-matter-precise-treatment/
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Walsh Resources and References
http://corepsych.com/walsh-resources
Epigenetics reviewed through videos in 2 playlists and 1 Walsh Presentation.
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PS: Don't Forget This TotallyADD Recording
Register for, and make sure you go back to watch, our Rick Green/Parker Webinars as we discuss Why [Dig Deeper], How [Brain Function] and, in the third TotallyADD Webinar, What [To Explore] series. Topics: psychiatric diagnosis and treatment for ADHD/Executive Function. Mind science is slowly but inexorably changing. Watch the first two meetings to prepare for our anticipated discussion about Dr Walsh's laboratory measurements and nutrient interventions in the third webinar. Details matter.
NB: The first Why Webinar is now recorded and ready for review. Prepare for How coming on Oct. 19, available here:
http://totallyadd.com/webinar-archives/
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Do subscribe below for future CorePsych updates, and please forward these important new data-tools to your colleagues.
cp
Dr Charles Parker
Connect & Subscribe To CorePsych News: This Link
Connect & Subscribe For YouTube Updates: This Link
Complimentary & New: 23 pg Special Report: Predictable Solutions For ADHD Medications
Book: New ADHD Med Rules: http://amzn.to/1zeDMga
Footnotes
1 Walsh, WJ, Nutrient Power – Heal Your Biochemistry and Heal Your Brain, Skyhorse Publishing 2012, p 74-75.
2 Ibid., p 73.
3 Ibid., p 150.
4 Walsh WJ, Rehman F. (1997). Methylation syndromes in mental illness. Abstracts: Society for Neuroscience 27th Annual Meeting (pt 2). New Orleans, LA, October 25-29.
5 Suzuki MM, Bird AP. (2008 ). DNA methylation landscapes: provocative insights from epigenomics. Nat Rev. Genet. 9 (6): 465-476.
6 Walsh WJ, Glab LB, Haakenson ML. (2004). Reduced violent behavior following biochemical therapy. Physiol Behav. 82: 835-839.
7 http://hmg.oxfordjournals.org/content/14/suppl_1/R139.long
22 Comments
[…] significant number of undermethylated depression patients exhibit some degree of pyrrole disorder. Many persons with this combination of imbalances […]
Hi Dr. Parker,
I began taking methylfolate (500mcg per day) and methyl b12 (1000 mcg per day) about a week ago and couldn’t believe how amazing I felt. I struggle with depression and ADD and I felt like a fog was lifted from my brain. I also continued to take 5mg of Adderall twice per day. I continued to feel great for about two more days and then it seemed like everything slowly went downhill from there. I wasn’t experiencing the same effects from the supplements. The past two days, I felt absolutely awful. The best way I can describe it is that I felt anxious, restless, apathetic, and just totally down. Do you have any idea why I might have experienced such amazing symptom relief followed by a total worsening of symptoms? Thank you!
Kelly,
If you notice in the vids on this page you can see that methyl is good if undermethylated and folate is for overmethylation. See this podcast wherein I interview Dr Walsh on these very issues: http://corebrainjournal.com/025
cp
[…] persons diagnosed with oppositional-defiant disorder were undermethylated. William Walsh, […]
Lovely! So glad you’ve all heard of each other — Mensah Medical is probably the best clinic us Chicagoland natives have access to in terms of a doctor who’s willing to dig deeper into root causes for psychological/cognitive dysfunctions. Last summer (2013), I was conflicted between going to Mensah Medical or your practice in Virginia Beach to dig deeper and get as many informative labs ordered as possible (especially since, due to hitting rock bottom in treatment progress, i’d reached my maximum out of pocket w/ insurance for the year). I had to end up going with M.M. since insurance approved me for TMS treatment for a solid 8 or so weeks thru my local pdocs office.
I think the Walsh Biotypes are an essential methodology to include in one’s constructively diagnostic toolkit, but unfortunately the two doctors I met with were hyperfocused on these main biotypes throughout my entire appointment (cost nearly a grand in the end…best 22nd birthday gift ever, said no one ever). For example, they refused to order any kind of quality NT testing amongst several others – and I had to beg for a GPL OATs, basic labcorp lyme disease, blood typing (to check for A certain type, which Walsh has plainly noted interferes with treatment outcome timeframes/expectations, IgG foods, homocysteine, and vitamin D.
Sigh. Cookie-Cuttered mindsets almost everywhere these days; so frustrating – especially for the patient who’s enjoyed spending his too many semesters of medical leave from college keeping himself well-informed of current tools available to practitioners – especially the quality/variety/specificity of those few innovative laboratories out there.
Michael,
After I’ve seen them [assuming you’re speaking about Dr M and Dr B] in action for 5 days at the meetings I can tell you that you and I were in very good company. All of us know a piece. Reality is difficult to touch, harder to embrace. They know that Walsh piece very darn well, and few do. Without looking at your results I can say that I might, however, possibly agree with you on one point: yeast, IgG, homocysteine, would be useful. If they didn’t request those they had a clear reason. Without knowing exactly what happened I can say with considerable certainty that they are much into these tests – but suspect some other variables supervened.
One other somewhat exculpatory note: devoted as I am to NT testing, with years of experience, I can tell you, even tho I’m a relative novitiate, that I have high confidence in adding the Walsh Protocol details to CorePsych and have enjoyed some very interesting and positive conversations even at this innocent level of experience. NT testing is falling quick into less importance unless easily supported by acceptable ROI.
Whatever your results, stay w your program, sometimes these matters take time. Press on. The informed win far more often then the uninformed.
cp
Michael,
A small PS that might be of interest as I bring Dr Walsh into a video/webinar/ADHD discussion: http://corepsych.com/totallyadd-what-video
Rick Green and his crew were great fun to work with.
cp
[…] week I spent 5 days with Dr Bill Walsh at the Walsh Institute learning key clinical details on Walsh Protocols- and I strongly encourage any medical colleagues […]
[…] Bill Walsh is a serious research pioneer and critical thinker on the practicality of using epigenetic applications in mind science to solve the remarkable array of missed targets present in current psychiatric treatment. Applications work, but only if you know how to measure and use them in an office practice. Precision with useful details matter. […]
[…] Walsh Depression #5 – This is the last in a series [WD1: Undermethylation here, | WD2: Overmethylation here | WD3: Copper Excess here | WD4: Pyrrole Disorder here] of 5 posts on […]
[…] Walsh Depression #4 – This is the fourth in a series [WD1: Undermethylation here, | WD2: Overmethylation here | WD3: Copper Excess here] of 5 posts on Dr Bill Walsh’s 5 […]
[…] Walsh Depression #3 – This is the third in a series [WD1: Undermethylation here, | WD2: Overmethylation here] of 5 posts on Dr Bill Walsh’s 5 biotypes of depression as […]
[…] Walsh Depression #2 – This is the second in a series [WD1 here] of 5 posts on Dr Bill Walsh’s 5 biotypes of depression as described in his book Nutrient […]
[…] proves ineffective no matter what treatment strategy – unless it’s first corrected. New data demonstrates the fact that changes between mind and body go both […]
Great article. Can’t wait to learn about this topic. Seems to me it has the potential to revolutionize our thinking about and treatment of depression. Thanks sooooo much for bringing this to our attention.
p.s. I can’t wait to read about the other types. I have found that I’ve noticed various “types” of depression in my own work with clients. So glad the nuances are being distinguished in a systematic way. : )
Ariane,
The details and testing are not only intriguing, they’re cost effective on the laboratory side.
Chuck
Araine,
Bill’s data, his collective peer reviewed observations, will add remarkably to our current neuroscience tool box – thanks for weighing in! Hope all is well.
Chuck
My son has had Major Depression with Suicide thoughts. He has tried suicide at least 3 times. The last time he shot himself at the bottom of his heart and lived. He had surgery where they repaired his heart and took part of a lung that he damaged. At this time he is in the Larned State Hospital, Adult Disability Unit. He can not get the Suicide thoughts out of his mind. He has and knows that he has so much to live for, but the thoughts always are there. He has been in and out of different behavior units a least 8 times in the last 3 1/2 years, including Menniger’s in Houston, TX for 8weeks this spring and prove to be very unsatisfactory. When he came home for there, he just felt like there was nothing more out there for him. Two weeks later, he shot himself.
A year ago he was diagnosed with Adult ADHD and was treated for it. But has been taken of the Meds for it several months ago. This where I heard about Dr Parker’s work and have several of his books.
He also had a blood test that shows up the blood mutation “MTHFR
He has been on so many med’s. At this time, he is on Lithium, Zoloft, Cymbalta . The Lithium make his shake tremendously. AT one time, they had him on “deplin” but took him off over a year ago. The main problem that I see, is that he has had so many different Psychiatrists and Social Workers that no one has kept up with his treatment.
We are desperate to find an answer or some kind of info for us to be able to help him with living.
Kathy,
Given his acuity and complexity I would suggest a consult with Mensah Medical near Chicago as they deal with these more acute situations. He sounds very much like a biomedical conundrum – and they have worked with Walsh Protocols for many years.
Deplin can cause a problem with some subsets of depression, and that same subset often reacts poorly to SSRI meds.
cp
Thank you for your quick response, Dr Parker! I have studied the “Mensah Medical” web-site you sent and am very excited about what they offer. My son has a daughter who is graduating from Logan Chiropractic School in December. I have shared your e-mail with her, so she can study what you have recommended. Hopefully we can plan to get him up to Mensah Medical when we get him out of the Larned Hospital.
Again, thank you, now we can go forward with a new outlook for him.
God Bless you,
Kathy Stegman
Kathy,
Great! Do please keep me posted. He sounds on very little info like a guy on the overmethylated side of things – will be interested to hear what they say.
cp