Issues with the purported inadequacy of nutritional supplements do parallel the overwhelming public angst over the limitations of psychiatric medications themselves.
Pyrrole disorder is one you must absolutely consider in treatment resistant depression: Severe pyrrole levels have been observed in persons diagnosed with violent behaviors, depression, schizophrenia, and other serious mental disorders.
Copper-overloaded depressives usually report that serotonin-enhancing antidepressants provide improvement in moods, but they worsen anxiety. Estrogen and adrenal imbalances frequently associated.
Bill Walsh is a mind pioneer. This brief video on one depression biotype - undermethylation - [1 of 5] will likely whet your appetite on the fact that depression is more than just an appearance of sadness.