Copper-overloaded depressives usually report that serotonin-enhancing antidepressants provide improvement in moods, but they worsen anxiety. Estrogen and adrenal imbalances frequently associated.
This brief video on the Walsh overmethylation - folate deficiency depression biotype [2 of 5] - will remind you of the the fact that depression is more than just an appearance of sadness.
The current diagnostic coding system often works fairly well, but let's do call a spade a spade. If it isn't adequate let's consider improving our thinking, our perceptual apparatus, and reframe outdated dogma.