Schizophrenia and Celiac? SPECT Brain Evidence

Brain evidence though SPECT imaging confirms out clinical observations about celiac, gluten sensitivity and severe psychiatric symptoms. – And it was written in 1997!

From the Journal of Internal Medicine:

A 33-year-old
patient, with pre-existing diagnosis of ‘schizophrenic' disorder, came
to our observation for severe diarrhoea and weight loss. Use of single

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photon emission computed tomography, (99mTc)HMPAO SPECT, demonstrated
hypoperfusion of the left frontal brain area, without evidence of
structural cerebral abnormalities. Jejunal biopsy showed villous
atrophy. Antiendomysial antibodies were present. A gluten-free diet was
started, resulting in a disappearance of psychiatric symptoms, and
normalization of histological duodenal findings and of (99mTc)HMPAO
SPECT pattern. This is the first case in which, in an undiagnosed and
untreated coeliac patient with psychiatric manifestations, the
(99mTc) HMPAO SPECT demonstrated a dysfunction of frontal cortex
disappearing after a gluten-free diet.

Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free dietDe Santis A, Addolorato G, Romito A, Caputo S, Giordano A, Gambassi G, Taranto C, Manna R, Gasbarrini G, Department of Internal Medicine, Catholic University, Rome, Italy J Intern Med. 1997 Nov;242(5):421-3

Always good to check out the available references!

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